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Q.
Haemoglobin is having maximum affinity with
AMUAMU 2001
Solution:
Haemoglobin has maximum affinity with carbon monoxide. $CO$ combines with haemoglobin more rapidly than oxygen t form carboxy haemoglobin. It has $200-250$ times more affinity for haemoglobin as compared to oxygen. Formation of carboxyhaemoglobin decreases the overall $O _{2}$ carrying capacity of blood to cell resulting into oxygen deficiency- hypoxia. Most of oxygen is transported in the form of oxyhaemoglobin. One molecule of haemoglobin readily combines with 4 molecules of oxygen.
$Hb +4 O _{2} \rightleftharpoons HbO _{2}$ (oxyhaemoglobin) Formation of oxyhaemoglobin depends on pH, $P _{ CO _{2}}$ and temperature. Haemoglobin also has affinity for $CO _{2}$. About $23 \%$ of total blood $CO _{2}$ is transported by loosely binding with haemoglobin forming a unstable compound called carbamino haemoglobin.