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Q.
Given pedigree shows inheritance of autosomal recessive gene. What is the genotype of given parents?
NTA AbhyasNTA Abhyas 2020Principles of Inheritance and Variation
Solution:
In the above pedigree, female parent B is affected by the disease. In autosomal recessive disorder, the person can be diseased only if it has a homozygous recessive genotype. Thus genotype of B is aa. Male Parent A is unaffected. In autosomal recessive condition, the unaffected individual can occur when the genotype is AA or Aa. In the cross between AA x aa, all offsprings will be Aa and will not suffer from the disease. In the cross between Aa x aa, half the offsprings will be Aa (unaffected) while the remaining half will be aa (affected). In the given pedigree no of their children are affected, so the male parents genotype should be AA
