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Q. Failure of segregation of chromatids during cell division results in the gain or loss of chromosomes, this is called as _____.

NTA AbhyasNTA Abhyas 2022

Solution:

When there is the presence of fewer or extra chromosomes than the normal genome number of the species is called aneuploidy (heteroploidy). During the gamete formation process by meiosis, there is a chance the two chromosomes of homologous pair do not separate resulting in one gamete will have an extra chromosome $\left(\right.N \, + \, 1\left.\right)$ while the other becomes deficient in one chromosome $\left(\right.N-1\left.\right)$ . This results in aneuploidy. The resulting zygote either will be deficient in chromosomes or has additional chromosomes.
Aneuploidy can also be defined as the presence of an abnormal number of chromosomes in a cell, for example, a human cell having 45 or 47 chromosomes instead of the usual 46.