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  4. During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it's DNA-binding sequence ?

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Q. During transcription, $RNA$ polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it's $DNA$-binding sequence ?

AIPMTAIPMT 2007Molecular Basis of Inheritance

Solution:

TATA box is present in eukaryotic promotor region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle-like structure at this place.