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  4. During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle-like structure at that point. This sequence is

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Q. During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle-like structure at that point. This sequence is

NTA AbhyasNTA Abhyas 2020Molecular Basis of Inheritance

Solution:

TATA box is present in the eukaryotic promoter region. It has a resemblance with the Pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is also called a Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription the RNA polymerase (a holoenzyme which has a core unit and a Sigma factor for proper initiation of transcription) binds to the TATA box due to which DNA assumes a saddle-like structure at this place.