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  4. Dissociation curve shifts to the right when

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Q. Dissociation curve shifts to the right when

Chhattisgarh PMTChhattisgarh PMT 2007

Solution:

The percentage of hemoglobin that is bound with $C_{2}$ is called percent saturation of hemoglobin. It depends upon the partial pressure of oxygen $\left( Po _{2}\right)$ in blood. The relationship between $\left( Po _{2}\right)$ and percentage saturation of hemoglobin with $O _{2}$ is graphically illustrated by a curve called oxygen hemoglobin dissociation curve. Changes in body temperature and blood $pH$ as well as, in the concentrations of $CO _{2}$ in blood and of $2, 3$ diphosphnglvcerate in red blood corpuscles affect the oxygen affinity of hemoglobin resulting into a shifting of the $O _{2}$ hemoglobin dissociation curve. When partial pressure of $CO _{2}$ rises (blood pH decreases dissociation curve of oxyhaemoglobin at $37^{\circ} C$ shift to right.