Q. Cope reaction is
CMC MedicalCMC Medical 2015
Solution:
Cope reaction is $ {{E}_{2}} $ intra-molecular. ? Cope elimination is a syn-elimination and proceeds through a cyclic transition state. ? The negatively charged oxygen of the amine oxide is the base that remove a proton from $ \beta \text{-} $ carbon. ? Because the nucleophiles and leaving group are in same molecule, this is an intra-molecular $ {{E}_{2}} $ reaction and give less substituted alkene as the major product.
