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  4. Conversion of phosphoglyceraldehyde to 1, 3- biphosphogly eerie acid is a

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Q. Conversion of phosphoglyceraldehyde to 1, 3- biphosphogly eerie acid is a

AMUAMU 1998

Solution:

: During the glycolytic pathway (dehydrogenation and phosphorylation), in the presence of enzyme glyceraldehyde phosphate dehydrogenase, glyceraldehyde 3-phosphate loses hydrogen to NAD to from $ NAD{{H}_{2}} $ and accepts inorganic phosphate to form $ 1:3 $ diphosphoglycerate. Glyceraldehyde 3 - phosphate $ +{{H}_{3}}P{{O}_{4}}+NA{{D}^{+}} $ $ 1:3 $ phosphoglycerate $ +NADH+{{H}^{+}} $ One of the two phosphates of diphos-phoglycerate is linked by high energy bond. It can synthesis ATP and form 3-phosphoglycerate by using the enzyme phosphoglycerate kinase. The direct synthesis of ATP from metabolites is called substrate level phosphorylation. $ 1:3 $ diphosphoglycerat $ +ADP $ 3 - phosphoglycerate + ATP.