1. Tardigrade
  2. Question
  3. Biology
  4. Colchicine is a chemical that stops chromatids from separating during mitosis. If a cell is treated with colchicine, at which stage of mitosis will this cell reach but not complete?

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Q. Colchicine is a chemical that stops chromatids from separating during mitosis. If a cell is treated with colchicine, at which stage of mitosis will this cell reach but not complete?

NTA AbhyasNTA Abhyas 2020Cell Cycle and Cell Division

Solution:

Colchicine is a mitotic inhibitor. It does not allow spindle fibres to be formed. Thus, condensation of chromosomes will occur and prophase will be completed. But metaphase won't be completed. The metaphase stage is characterized by all the chromosomes coming to lie at the equator with one chromatid of each chromosome connected by its kinetochore to spindle fibres from one pole and its sister chromatid connected by its kinetochore to spindle fibres from the opposite pole.