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  4. Child death may occur in the marriage of

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Q. Child death may occur in the marriage of

AIPMTAIPMT 1988Body Fluids and Circulation

Solution:

Rh factor plays a crucial role in child's birth born out of a marriage between Rh woman and a Rh+ man. In such a case, the mother becomes sensitive while carrying a first Rh+ child within her womb. The reason for such sensitivity is that some of the RBCs from the developing embryo get into the blood stream of the mother during development, causing her to produce anti-Rh antibodies. In fact, the first child of such parents is nearly normal and is delivered safely. However, if such a mother gets pregnant again, the subsequent Rh+ foetuses will be exposed to the anti-Rh antibodies produced by the mother. As a result serious damage to the red blood cells of the developing embryo will occur causing haemolytic disease of the newborn (HDN) or erythroblastosis foetalis. This disease leads to the death of the developing embryo before birth or after parturition.