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  4. Assertion: Prophase is the first stage of mitosis which follows S and G1 phases of interphase. Reason :: Prophase is marked by the initiation of clusters of chromosomes.

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Q. Assertion : Prophase is the first stage of mitosis which follows $S$ and $G_{1}$ phases of interphase.
Reason :: Prophase is marked by the initiation of clusters of chromosomes.

Cell Cycle and Cell Division

Solution:

Prophasewvhich is the first stage of mitosis follows the $S$ and $G_{2}$ phases of interphase. In the $S$ and $G_{2}$ phases the new $DNA$ molecules formed are not distinct but interwined. Prophase is marked by the initiation of condensation of chromosomal material. The chromosomal material becomes untangled during the process of chromatin condensation.