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  4. Assertion: Insulin forms hormone receptor complex which regulate gene expression. Reason: Insulin is a peptide hormone which can easily pass cell membrane to interact with hormone-receptor complex.

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Q. Assertion : Insulin forms hormone receptor complex which regulate gene expression.
Reason : Insulin is a peptide hormone which can easily pass cell membrane to interact with hormone-receptor complex.

AIIMSAIIMS 2019Chemical Coordination and Integration

Solution:

Insulin is a protein hormone which is water soluble. Water soluble hormones require extracellular receptors that generate second messengers for carrying out their activity. Insulin binds to its specific receptor molecule located on the plasma membrane to form the hormone receptor complex, $(HRC)$ which in turn generate second messengers that regulate cellular mechanism. Water soluble hormones (e.g., amino acid derivatives, peptides and protein hormones) do not enter the target cell.