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  4. Assertion: In malaria, a person experiences chills and high fever recurring every three to four days. Reason: This is caused by the release of haemozoin with rupture of liver cells.

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Q. Assertion : In malaria, a person experiences chills and high fever recurring every three to four days.
Reason : This is caused by the release of haemozoin with rupture of liver cells.

Human Health and Disease

Solution:

Malignant malaria caused by Plasmodium falciparum is the most serious one and can even be fatal. The parasites initially multiply within the liver cells and then attack the red blood cells $(RBCs)$ resulting in their rupture. The rupture of $RBCs$ is associated with release of a toxic subtance, haemozoin, which is responsible for the chill and high fever recurring every three to four days.