Question

Assertion : Hb^s Hb^s denotes the homozygous condition for sickle-cell anaemia.
Reason : It occurs due to substitution of glutamic acid by valine at the 6^th position of β-chain of Hb.

• A. If both assertion and reason are true and reason is the correct explanation of assertion
• B. If both assertion and reason are true but reason is not the correct explanation of assertion
• C. If assertion is true but reason is false
• D. If both assertion and reason are false

Answer 1

Answer: (B)

Sickle cell anaemia is an autosomal hereditary disorder in which the erythrocytes become sickle shaped. The disorder or disease is caused by the formation of an abnormal haemoglobin called haemoglobin-s denoted as Hbs. Thus, the genotype of an individual homozygous for sickle cell anaemia is wri􀄴en as HbsHbs