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  4. Assertion: A change in nitrogen base at the third position of a codon causes change in the expression of the codon. Reason: A codon is mostly read by all the three nitrogen bases.

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Q. Assertion : A change in nitrogen base at the third position of a codon causes change in the expression of the codon.
Reason : A codon is mostly read by all the three nitrogen bases.

Molecular Basis of Inheritance

Solution:

According to the Wobble hypothesis, only the first two position of a triplet codon on $mRNA$ have a precise pairing with the bases of the $tRNA$ anticodon. The pairing of the third position bases of the codon may be ambiguous and varies according to the nucleotide present in this position. Thus, a single $tRNA$ type is able to recognise two or more codons differing only in the third base. The same is called wobble position.