Menopause is a senile change that occurs in the ovaries around the age of 50 years. At this time, a woman no longer ovulates and thus moves out of the childbearing phase. All the ovarian follicles have degenerated and there is a deficiency of estrogen and progesterone hormone. FSH and LH are being produced by the anterior lobe of the pituitary, but now the ovary is not responding to these hormones. High levels of gonadotropins can also cause demineralization of bones, which leads to osteoporosis.
Hormone replacement therapy can alleviate the symptoms of menopausal syndrome.