Fact. Number of permutations of n things taken all at a time = Number of ways of particular things arc always together + particular things are never together.
Let 4 particular things denoted by k1,k2,k3,k4 arc as one thing. ∴ Total permutations = particular things always together + never together ⇒10!=(10−4+1)!4!+ Never together =7!4!+ Never together ∴ Particular 4 things never come together =10!−7!×4!